Nin Dingra, Ph.D.

Assistant Professor
Department of Chemistry
CPSB 302B
(907) 786-1332
ndingra@alaska.edu

Education

Ph.D. Chemistry, University of South Carolina, Columbia, SC, 2010
B.S. Chemistry, Georgia Southern University (formerly Armstrong State University), Savannah, GA, 2005

Teaching Responsibilities

CHEM A441 – Biochemistry I
CHEM A442 – Biochemistry II
CHEM A443L – Biochemistry laboratory

Research Interests

Carbon monoxide has recently been found to be produced endogenously and act as a signaling molecule in the body. Studies of CO have shown anti-inflammatory, anti-apoptotic and other cytoprotective effects although the exact mechanism of CO action is not well understood. Due to its physiological importance, gaseous CO has been used as a therapeutic agent in medical applications. However, gaseous CO is not a desired long-term therapy due to the difficulty in administration to the desired places and the toxic effect for inhalation. As a result, there is an increased interest in synthesizing carbon monoxide releasing molecules as an alternative to the CO gas. Discovery of new and diverse CORM that is capable of releasing controlled amounts of CO in physiological conditions is highly desirable. We are interested in preparing novel molecules that release CO yet with low cellular toxicity. Our studies include determining the actions of newly discovered carbon monoxide releasing carboxyboranes (CORCBs) and their interactions with reactive oxygen species. We are also interested in elucidating how CO exerts its effect at the cellular level especially to the redox balance.

Publications

“ROS-mediated Carbon Monoxide and Drug Release from Drug-conjugated Carboxyboranes” Ayudhya, T. I.; Pellechia, P. J.; Dingra, N. N. Dalton Transactions (2017) DOI: 10.1039/C7DT03581K     [Web Link]

“Experimental Crystal Structure Determination for Struvite, MgNH4PO4.6H2O” Witty, M.; Dingra, N. N.; Abboud, K. A.; Felts, A. C.; Ayudhya, T. I. CCDC 1492211: (2017) DOI: 10.5517/ccdc.csd.cc1m2rv9      [Web Link]

“Nuclear Magnetic Resonance and X-Ray Crystallography to Improve Struvite Determination” Witty, M.; Dingra, N. N.; Abboud, K. A.; Felts, A. C.; Israsena Na Ayudhya, T. Analytical Letters (2017): 16, 2549-2559.            [Web Link]

“Experimental Crystal Structure Determination of CORCB-1” Ayudhya, T. I.; Raymond, C. C.; Dingra, N. N. CCDC 1421389: (2017) DOI: 10.5517/ccdc.csd.cc1jq28l     [Web Link]      

“Hexamethylenetetramine carboxyborane: synthesis, structural characterization and CO releasing property” Ayudhya, T. I.; Raymond, C.; Dingra, N. N.; Dalton Transactions (2017): 46, 882-889.     [Web Link]

“Using a Microscale Approach To Rapidly Separate and Characterize Three Photosynthetic Pigment Species from Fern” Ayudhya, T.; Posey, F.; Tyus, J.; Dingra, N. N. Journal of Chemical Education (2015): 92, 920-923.            [Web Link]

“Histidine 103 in Fra2 is an Iron-Sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 Complex and Is Required for in Vivo Iron Signaling in Yeast” Li, H.; Mapolelo, D. T.; Dingra, N. N.; Keller, G.; Riggs-Gelasco, P. J.; Winge, D. R.; Johnson, M. K.; Outten, C. E.; Journal of Biological Chemistry (2011): 286(1), 867–876.     [Web Link]

"The yeast iron regulatory proteins Grx3/4 and Fra2 form heterodimeric complexes containing a [2Fe-2S] cluster with cysteinyl and histidyl ligation." Li, H.; Mapolelo, D. T.; Dingra, N. N.; Naik, S. G.; Lees, N. S.; Hoffman,B. M.; Riggs-Gelasco, P. J.; Huynh, B. H.; Johnson, M. K.; Outten, C. E.; Biochemistry (2009): 48, 9569-81.          [Web Link]

“Structure of the thioredoxin-like domain of yeast glutaredoxin 3” Gibson, L. M.; Dingra, N. N.; Outten, C. E.; Lebioda, L. Acta Crystallography D (2008): 64, 927–932.     [Web Link]

“Identification of FRA1 and FRA2 as Genes Involved in Regulating the Yeast Iron Regulon in Response to Decreased Mitochondrial Iron-Sulfur Cluster Synthesis” Kumánovics, A.; Chen, O. S.; Li, L.; Bagley, D.; Adkins, E. M.; Lin, H.; Dingra, N. N.; Outten, C. E.; Keller, G.; Winge, D.; Ward, D. M.; Kaplan, J.; Journal of Biological Chemistry (2008): 283(16), 10276-10286.    [Web Link]

“Infusion of Nanotechnology in Chemistry Courses Through Laboratory Redesign and Vertical Threads” Nivens, D. A.; Lynch, W. E.; Helmly, B. C.; Nguyen, N. T.; Dingra, N. N.; Chow, J.; Svendsen, A.; Harris, B. D.; Meeks, A.; Dyal, C.; Hadden, J.; Tibah, D. M.; E-Proceedings of the Materials Research Society (2006): 931, KK03-01.             [Web Link]

“Nanoparticle mediated photodefluorination monitored by 19F NMR” Chow, J.; Dingra, N. N.; Baker, E.; Helmly, B. C.; Nivens, D. A.; Lynch, W. E.; Journal of Photochemistry and Photobiology A: Chemistry (2005): 173(2), 156-160.         [Web Link]