Dr. Eric G. Holmberg

Professor of Chemistry
Office: CPSB 302 J
Phone: (907) 786-1289
Email: egholmberg@uaa.alaska.edu


Eric G. Holmberg, Ph.D. is a biochemist with several research interests. He has published many peer-reviewed articles and has been teaching for over 20 years.


Ph.D. in Biophysical Chemistry, SUNY, Binghamton, 1987.

B.S. in Biochemistry, Niagara University, Lewiston, NY, 1983.

Career History

7/04 - 6/15 University of Alaska Anchorage
Department of Chemistry

4/02 - Present Spinal Cord Society Research Center, Fort Collins, Colorado
Staff of ten scientists, budget of $1 million / year
Research Director

7/89 - Present
University of Alaska Anchorage
Chemistry Department
Professor of Chemistry

6/95 - 8/95 University of Tennessee, Memphis
Department of Anatomy and Neurobiology, School of Medicine
Visiting Scientist

7/89 - 8/94 University of Alaska Anchorage
Department of Chemistry/Physics
Assistant Professor of Biochemistry; Instructor for WWAMI

6/87 - 7/89 University of Tennessee, Knoxville, Tennessee
Department of Biochemistry
Post-doctoral Research Associate
Senior Investigator: Professor Leaf Huang

1/88 - 7/88  National Heart Lung and Blood Institute, National Institutes of Health, at the Cardiology Research Center. Laboratory for Enzyme Engineering, Moscow, USSR
Research Exchange Scientist
Professor and Head: Vladimir P. Torchillin

9/83 - 5/87 SUNY, Chemistry Department, Binghamton
Lecturer, Research Assistant, Teaching Assistant

Teaching Responsibilities

Survey of Chemistry (CHEM 103) This course is designed to provide health science and liberal arts students with a general overview of basic chemical concepts.

Survey of Chemistry Laboratory (CHEM 103L) Introductory chemistry laboratory course with experiments designed to introduce students to the basics of laboratory equipment, data collection, data analysis and reporting; and to illustrate, augment and apply concepts covered in CHEM 103.

Introduction to Organic and Biochemistry (CHEM 104) This course is designed to provide health science and liberal arts students with a general overview of organic and biochemistry concepts.

General Chemistry (CHEM 105 - 106) This course covers all the basic concepts of chemistry.

Physical Chemistry: A Biological Orientation (CHEM 311) This course introduces the principles of physical chemistry to students primarily interested in the biochemical and biological aspects of chemistry.

Biophysical Chemistry (CHEM 411) Study of principles of thermodynamics, chemical kinetics, molecular kinetic theory and spectroscopy as applied to biochemical systems. Applications to solutions, phase equilibria, biochemical reactions, transport properties and spectroscopic techniques for biomolecular characterization. Introduction to computational techniques in physical chemistry.

Organic Chemistry (CHEM 321 - 322) This course investigates the chemistry of carbon compounds and discusses physical properties, nomenclature, synthesis, reactions, mechanisms, stereochemistry, and spectroscopic identification of these compounds.

Biochemistry / Advanced Biochemistry (CHEM 441 - 442) The first semester of this course covers the structure and function of amino acids, proteins, carbohydrates, nucleic acids, lipids, and membranes. The second semester looks at the bioenergetics and metabolic pathways of these compounds.

Research Interests

Dr. Holmberg's research interests include: 

- Stem cell utility for therapeutic paradigms.
- Repair and refunction in the central nervous system.
- Transformation of cells of the central nervous system via specific drug delivery vehicles.
- Factors affecting growth and function of the central nervous system.
- The effects of migration on the physiology of pacific salmon.
- Therapeutic drug delivery systems.
- Drug delivery by target-sensitive and pH-sensitive immunoliposomes.
- Immunochemistry of drug delivery.
- Proton flux in renal membrane vesicles.
- Physical interaction of organic pH sensitive molecules with artificial and biological transport in renal membrane vesicles.
- Binding of water transport inhibitors to red blood cell membranes.


  1. Zhang SX, Huang F, Gates M, Holmberg EG "Somatosensory evoked potentials can be recorded on the midline of the skull with subdermal electrodes in non-sedated rats elicited by magnetic stimulation of the tibial nerve." J. Neurosci. Methods. 2012 Jul 15; 208(2):114-8. Epub 2012 May 10.
  2. Zhang SX, Huang F, Gates M, Holmberg EG "Tail nerve electrical stimulation combined with scar ablation and neural transplantation promotes locomotor recovery in rats with chronically contused spinal cord." Brain Res. 2012 May 25; 1456:22-35. Epub 2012 Mar 29.
  3. Zhang SX, Huang F, Gates M, Holmberg EG "Scar ablation combined with LP/OEC transplantation promotes anatomical recovery and P0-positive myelination in chronically contused spinal cord of rats." Brain Res. 2011 Jul 5; 1399:1-14. Epub 2011 May 31.
  4. Zhang SX, Huang F, Gates M, White J, Holmberg EG "Histological repair of damaged spinal cord tissue from chronic contusion injury of rat: a LM observation." Histol. Histopathol. 2011 Jan:26(1):45-58.
  5. Shu-Xin Zhang and Eric G. Holmberg "Scar Removal, Tissue Repair and Physical Therapy - Strategies to Improve Functional Recovery of Chronic SCI." For the book entitled "Spinal Cord Injuries: Types, Treatments and Prognosis."
  6. Zhang SX, Huang F, Gates M, White J, Holmberg EG "Extensive scarring induced by chronic intrathecal tubing augmented cord tissue damage and worsened functional recovery after rat spinal cord injury." J. Neurosci Methods. 2010 Jun 30. [Epub ahead of print]
  7. Shu-Xin Zhang, Fengfa Huang, Jason White, Mary Gates and Eric G. Holmberg "Tail Nerve Electrical Stimulation Combined with Scar Ablation and Cell Transplantation Significantly Improves Functional Recovery in Chronically Contused Rat Spinal Cord." J. Neurosci. Meth., (2010), doi:10.1016/.j.jneumeth.2010.01.008.
  8. Holmberg E, Zhang S, Sarmiere P, Kluge B, White J and Doolen S "Statins decrease chondroitin sulfate proteoglycan expression and astrocyte activation in central nervous system injury." Experimental Neurology 214:78-86, 2008.
  9. Zhang SX, Holmberg EG, and Geddes JM "Artifactual dendritic beading in rat spinal cord induced by perfusion with cold saline and paraformaldehyde." Journal of Neuroscience Methods 163:38-43, 2007.
  10. Shu-Xin Zhang, Bridget Kluge, Fengfa Huang, Suzanne Doolen and Eric G. Holmberg "Photochemical Scar Ablation in Contused Spinal Cord of Rat." Journal of Neurotrauma 24:411-420, 2007.
  11. Zhang SX, Sarmiere P, Doolen S, Kluge B, Huang FF, White J, and Holmberg EG "Scar ablation combined with cell transplantation promotes tissue repair and axon regeneration in chronic contusion injury of rat spinal cord." Journal of Neurotrauma, Volume 24, Number 7, July 2007.
  12. Eric Holmberg, Bridget Kluge, Shu-Xin Zhang, Suzanne Doolen "Statin Treatment Decreases Presence of Scar Associated Molecules in Rat CNS Injury." Journal of Neurotrauma, Volume 23 Number 6 June 2006, pg 1012.
  13. Shu-Xin Zhang, James W. Geddes, Jesse L. Owens, Eric G Holmberg "X-irradiation Reduces Lesion Scarring at the Contusion Site of Adult Rat Spinal Cord." Histology and Histopathology, Apr 20(2): 519-30, 2005
  14. Gregory A. Helms, Eldon E. Geisert, Eric G. Holmberg, and John A. Jane "Distribution of Immunoliposomes in the CNS." Submitted, 1997.
  15. Eldon E. Geisert, Jr., Jesse L. Owens, and Eric G. Holmberg "Transfecting Neurons and Glia in the Rat CNS Using Immunoliposomes." Neurosci. Let., 184, 1-4, 1995.
  16. H. Suda, E.G. Holmberg, H.O. Nornes, and T. Neuman "Expression of E2F1 and E1A Induces DNA Synthesis in Differentiated Neurons In Vitro and In Vivo." NeuroReport, 5, 1749-1751, 1994.
  17. Eric G. Holmberg, Quentin Reuer, Eldon Geisert, and Jesse Owens "Liposomal Delivery of Plasmid DNA to Glial Cells." Biochem. Biophys.Res. Com., 201(2), 888-893, 1994.
  18. Eric G. Holmberg, and Nathan Turner "Effects of Migration on Proton Transport and Na+/H+ Exchange in Vesicles Isolated from Sockeye Salmon (Oncorhyncus nerka) Kidneys." Biochem. Biophys. Res. Com., 186(1), 24-31, 1992.
  19. G.W. Kabalka, M.A. Davis, E.G. Holmberg, K. Maruyama, and L. Huang "Gadolinium-Labeled Liposomes Containing Amphiphilic Gd-DTPA Derivatives of Varying Chain Length: Targeted MRI Contrast Agents for the Liver." Mag. Res Imag., 3, 374-376, 1991.
  20. G.W. Kabalka, M.A. Davis, E.G. Holmberg, K. Maruyama, and L. Huang, "Gadolinium-Labeled Liposomes Containing Various Amphiphillic Gd-DTPA Derivatives: Targeted MRI Contrast Enhancement Agents for the Liver." Mag. Res. 9, 373-377, 1991.
  21. G.W. Kabalka, M.A. Davis, T.H. Moss, E. Buonocore, K. Hubner, E. Holmberg, K. Maruyama, and L. Huang, "Gadolinium-Labeled Liposomes Containing Various Amphiphillic Gd-DTPA Derivatives: Targeted MRI Contrast Enhancement Agents for the Liver." Mag. Res. in Med. 19, 406-415, 1991.
  22. Eric G. Holmberg, Kazuo Maruyama, Stephen Kennel, Alexander Klibanov, Vladimir Torchillin, Una Ryan, and Leaf Huang, "Target-Specific Binding of Immunoliposomes In Vivo." J. Lip. Res. 1(4), 403-416, 1990.
  23. Kazuo Maruyama, Eric Holmberg, Stephen Kennel, Alexander Klibanov, Vladimir Torchilin, and Leaf Huang, "Characterization of In Vivo Immunoliposome Targeting to Pulmonary Endothelium." J. Pharm. Sci. 79(11), 978-984, 1990.
  24. Eric G. Holmberg, Kazuo Maruyama, David C. Litzinger, Stephen Wright, Mark Davis, George W. Kabalka, Stephen J. Kennel, and Leaf Huang, "Highly Efficient Immunoliposomes Prepared with a Method which is Compatible with Various Lipid Compositions." Biochem. Biophys. Res. Comm., 165, No. 3, 1272-1278, 1989.
  25. Eric G. Holmberg, A.S. Verkman, and James A. Dix, "Mechanism of Acridine Orange Interaction with Phospholipids and Proteins in Renal Microvillus Vesicles." Biophys. Chem., 33, 245-256, 1989.
  26. G.W. Kabalka, M. Davis, E. Buonocore, K. Hubner, E. Holmberg, and Leaf Huang, "Gd-Labeled Liposomes Containing Paramagnetic Amphiphiles." Contrast Media Research Conference Proceedings, Sidney and Hamilton Island, Australia, October 7, 1989. (in press)
  27. Eric G. Holmberg and Leaf Huang, "pH-sensitive and Target-sensitive Immunoliposomes for Drug Targeting." in Liposomes in the Therapy of Infectious Diseases and Cancer, UCLA Symposia on Molecular and Cellular Biology, New Series, Volume 89, Editor, G. Lopez-Berestein & I. Fidler, Alan R. Liss, Inc., New York, NY (1988).