Dr_Elvin_Brown

Chemistry Department - Term Assistant Professor

Office Location: 
NSB 121

Contact Information:
Phone #: (907) 786-1345
Fax #: (907) 786-4607
E-mail: eebrown@uaa.alaska.edu

Spring 2015 Office Hours:
  • TBA

Classes Taught - Past and Present:
  • Introduction to Organic Chemistry and Biochemistry - Chem 104
  • Introductory Biology - Biol 102
  • Human Anatomy and Physiology Lab - Biol 111L
  • Fundamentals of Biology I Lab - Biol 115L
  • Introductory Microbiology for Health Sciences Lab - Biol 240L

Degree(s):
  • B.S. Genetics, University of California, Berkeley, 1975.
  • Ph.D. Biochemistry and Molecular Biology, University of Alaska, Fairbanks, 2010.

Research Interests:
Development of the vertebrate embryo requires exquisite regulation of genes and cellular processes.  Working in the laboratory of Dr. Jocelyn Krebs, I am conducting loss of function experiments to study how an enzyme complex known as CHRAC regulates genes in development by altering the chromosome structure around them.  Collaborating with investigators in the Krebs lab and in laboratories at other institutions I am characterizing the role of CHRAC in morphogenesis and in gene regulation in frog embryos.  I use numerous techniques of molecular biology and computational molecular biology in this research.

Publications:
Smith, R.E. and Brown, E.E. (1998).  The significance of hypersialylation of Dipeptidyl Peptidase IV (CD26) in the inhibition of its activity by Tat and other cationic peptides. Aids Research and Human Retroviruses 14:851-868.

Brown, E.E., Malakar, S., and Krebs, J.E. (2007).  How many remodelers does it take to make a brain?  Diverse and cooperative roles of ATP-dependent chromatin-remodeling complexes in development. Biochemistry and Cell Biology 85:444-462.

Patent:
Smith, R.E. and Brown, E.E. (1989).  Method for the colorimetric determination of DPP-IV activity using cinnamaldehyde.  Application for U.S. Patent awarded 1989.

Published Abstracts:
Brown, E.E. and J.E. Krebs (2004).  SWI2/SNF2 homologs in Xenopus. Biochemistry and Cell Biology 82:517.

Brown, E.E., J.J. Henry, and J.E. Krebs (2009).  Developmental roles of the histone fold protein CHRAC17 in Xenopus.  Biochemistry and Cell Biology 87:821.